PHARMACOKINETICS AND METABOLISM OF QUINIDINE IN EXTENSIVE AND POOR METABOLIZERS OF SPARTEINE

被引：46

作者：

MIKUS, G

HA, HR

VOZEH, S

ZEKORN, C

FOLLATH, F

EICHELBAUM, M

机构：

[1] KANTONSSPITAL,DEPT INNERE MED,DIV CLIN PHARMACOL,CH-4004 BASEL,SWITZERLAND

[2] UNIV BONN,MED KLIN,D-5300 BONN,FED REP GER

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1986年 / 31卷 / 01期

关键词：

D O I：

10.1007/BF00870989

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：69 / 72

页数：4

共 15 条

[1] GENETIC-POLYMORPHISM IN DRUG OXIDATION - INVITRO STUDIES OF HUMAN DEBRISOQUINE 4-HYDROXYLASE AND BUFURALOL 1'-HYDROXYLASE ACTIVITIES [J].

BOOBIS, AR ;

MURRAY, S ;

HAMPDEN, CE ;

DAVIES, DS .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (01) :65-71

[2] EFFECT OF OXIDATIVE POLYMORPHISM (DEBRISOQUINE SPARTEINE TYPE) ON HEPATIC 1ST-PASS METABOLISM OF BUFURALOL [J].

DAYER, P ;

BALANT, L ;

KUPFER, A ;

STRIBERNI, R ;

LEEMANN, T .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 28 (03) :317-320

[3] INFLUENCE OF THE DEFECTIVE METABOLISM OF SPARTEINE ON ITS PHARMACOKINETICS [J].

EICHELBAUM, M ;

SPANNBRUCKER, N ;

DENGLER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :189-194

[4] POLYMORPHIC OXIDATION OF SPARTEINE AND DEBRISOQUINE - RELATED PHARMACOGENETIC ENTITIES [J].

EICHELBAUM, M ;

BERTILSSON, L ;

SAWE, J ;

ZEKORN, C .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1982, 31 (02) :184-186

[5]

EICHELBAUM M, 1984, FED PROC, V43, P2298

[6]

EICHELBAUM M, 1982, CLIN PHARMACOKINET, V7, P1, DOI 10.2165/00003088-198207010-00001

[7]

IDLE JR, 1984, 2ND P WORLD C CLIN P, P148

[8] A HUMAN CYTOCHROME-P-450 CHARACTERIZED BY INHIBITION STUDIES AS THE SPARTEINE DEBRISOQUINE MONOOXYGENASE [J].

INABA, T ;

NAKANO, M ;

OTTON, SV ;

MAHON, WA ;

KALOW, W .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1984, 62 (07) :860-862

[9] DEFECTIVE METABOLISM OF METOPROLOL IN POOR HYDROXYLATORS OF DEBRISOQUINE [J].

LENNARD, MS ;

SILAS, JH ;

FREESTONE, S ;

TREVETHICK, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 14 (02) :301-303

[10]

LEROYER R, 1982, J CHROAMTOGR BIOCH A, V228, P336

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