SURFACE MODIFICATION OF POLYURETHANE FOR ENHANCED BLOOD COMPATIBILITY

被引：10

作者：

KIM, YH

HAN, DK

JEONG, SY

AHN, KD

机构：

[1] Polymer Chemistry Laboratory, Korea Advanced Institute of Science and Technology, Seoul, P.O. Box 131, Cheongryang

来源：

MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA | 1990年 / 33卷

关键词：

D O I：

10.1002/masy.19900330127

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Surfaces of commercial polyurethanes (PUs) were modified by poly(ethylene oxide) (PEO) grafting and/or heparin immobilization or sulfonation to investigate the effect to antithrombogenicity. The hydrophilicity of the modified PUs surface was significantly increased. All the PEO‐grafted PU surfaces displayed very little platelet adhesion and activation. The coupled heparin or sulfonate at the end of PEO exhibited anticoagulant activity to extend APTT. Lowering in vitro platelet adhesion of modified PUs led to a prolongation in the ex vivo occlusion time. In particular, the sulfonated PU‐PEO surface showed the most enhanced blood compatibility due to the synergistic effects of PEO and SO3 groups. Copyright © 1990 Hüthig & Wepf Verlag

引用

页码：319 / 326

页数：8

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