DNA LOOPS - STRUCTURAL AND FUNCTIONAL-PROPERTIES OF SCAFFOLD-ATTACHED REGIONS

被引：69

作者：

ROBERGE, M ^{[1
]}

GASSER, SM ^{[1
]}

机构：

[1] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

MOLECULAR MICROBIOLOGY | 1992年 / 6卷 / 04期

关键词：

D O I：

10.1111/j.1365-2958.1992.tb01485.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The long DNA molecules of eukaryotic genomes appear to be organized into large loops formed by the binding of dispersed DNA sequences to non-histone proteins. This partitioning of DNA into topologically constrained units constitutes one of the highest orders of DNA packing in chromosomes. DNA loops are likely to define functional units as well as topological domains, contributing to the regulation of gene expression and DNA replication. This review presents recent work on the properties of the DNA sequences and proteins thought to be involved in loop formation, and on their possible significance for replication and transcription.

引用

页码：419 / 423

页数：5

共 48 条

[1] PREFERENTIAL, COOPERATIVE BINDING OF DNA TOPOISOMERASE-II TO SCAFFOLD-ASSOCIATED REGIONS [J].

ADACHI, Y ;

KAS, E ;

LAEMMLI, UK .

EMBO JOURNAL, 1989, 8 (13) :3997-4006

[2] DROSOPHILA SCAFFOLD-ATTACHED REGIONS BIND NUCLEAR SCAFFOLDS AND CAN FUNCTION AS ARS ELEMENTS IN BOTH BUDDING AND FISSION YEASTS [J].

AMATI, B ;

GASSER, SM .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5442-5454

[3] NUCLEAR SCAFFOLD ATTACHMENT STIMULATES, BUT IS NOT ESSENTIAL FOR ARS ACTIVITY IN SACCHAROMYCES-CEREVISIAE - ANALYSIS OF THE DROSOPHILA-FTZ SAR [J].

AMATI, B ;

PICK, L ;

LAROCHE, T ;

GASSER, SM .

EMBO JOURNAL, 1990, 9 (12) :4007-4016

[4]

AMATI B, 1990, THESIS FS U LAUSANNE

[5] CHROMOSOMAL ARS AND CEN ELEMENTS BIND SPECIFICALLY TO THE YEAST NUCLEAR SCAFFOLD [J].

AMATI, BB ;

GASSER, SM .

CELL, 1988, 54 (07) :967-978

[6] DETECTION, SEQUENCE PATTERNS AND FUNCTION OF UNUSUAL DNA STRUCTURES [J].

ANDERSON, JN .

NUCLEIC ACIDS RESEARCH, 1986, 14 (21) :8513-8533

[7] INSITU LOCALIZATION OF DNA TOPOISOMERASE-II, A MAJOR POLYPEPTIDE COMPONENT OF THE DROSOPHILA NUCLEAR MATRIX-FRACTION [J].

BERRIOS, M ;

OSHEROFF, N ;

FISHER, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4142-4146

[8]

BLASQUEZ VC, 1989, J BIOL CHEM, V264, P21183

[9] CHROMATIN DOMAIN SURROUNDING THE HUMAN INTERFERON-BETA GENE AS DEFINED BY SCAFFOLD-ATTACHED REGIONS [J].

BODE, J ;

MAASS, K .

BIOCHEMISTRY, 1988, 27 (13) :4706-4711

[10] STUDIES OF AN 800-KILOBASE DNA STRETCH OF THE DROSOPHILA-X CHROMOSOME - COMAPPING OF A SUBCLASS OF SCAFFOLD-ATTACHED REGIONS WITH SEQUENCES ABLE TO REPLICATE AUTONOMOUSLY IN SACCHAROMYCES-CEREVISIAE [J].

BRUN, C ;

QI, D ;

MIASSOD, R .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5455-5463

← 1 2 3 4 5 →