INDEPENDENT CELLULAR AND ONTOGENIC EXPRESSION OF MESSENGER-RNAS ENCODING 3 ALPHA POLYPEPTIDES OF THE RAT GABA-A RECEPTOR

被引：113

作者：

MACLENNAN, AJ

BRECHA, N

KHRESTCHATISKY, M

STERNINI, C

TILLAKARATNE, NJK

CHIANG, MY

ANDERSON, K

LAI, M

TOBIN, AJ

机构：

[1] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,DEPT MED,LOS ANGELES,CA 90024

[5] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[6] VET ADM MED CTR BRENTWOOD,CTR ULCER RES,LOS ANGELES,CA 90073

来源：

NEUROSCIENCE | 1991年 / 43卷 / 2-3期

关键词：

D O I：

10.1016/0306-4522(91)90301-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that several distinct but related polypeptides can serve as alpha-subunits of functional GABA(A) receptors. Furthermore, the diversity of these polypeptides at least partially accounts for the functional heterogeneity of GABA(A) receptors. In this paper, we report the results of in situ hybridization studies using probes derived from our recently reported cDNAs for alpha-1, alpha-2, and alpha-4 GABA(A) receptor polypeptides. We show that the mRNAs that encode these isoforms have distinct regional and cellular distributions and are present at widely varying levels within the rat brain. In addition, our Northern blot analyses indicate that each of these three-alpha mRNAs has a distinct pattern of ontogenetic regulation. Differential regulation of alpha-polypeptide isoforms may lead to changes in GABA(A) receptor function during ontogeny as well as to distinct cellular response to GABA and GABA-related drugs.

引用

页码：369 / 380

页数：12

共 42 条

[1] COMMISSURAL CONNECTIONS OF THE HIPPOCAMPAL REGION IN THE RAT, WITH SPECIAL REFERENCE TO THEIR MODE OF TERMINATION [J].