AN ESR-CT IMAGING OF THE HEAD OF A LIVING RAT RECEIVING AN ADMINISTRATION OF A NITROXIDE RADICAL

被引：86

作者：

ISHIDA, S ^{[1
]}

MATSUMOTO, S ^{[1
]}

YOKOYAMA, H ^{[1
]}

MORI, N ^{[1
]}

KUMASHIRO, H ^{[1
]}

TSUCHIHASHI, N ^{[1
]}

OGATA, T ^{[1
]}

YAMADA, M ^{[1
]}

ONO, M ^{[1
]}

KITAJIMA, T ^{[1
]}

KAMADA, H ^{[1
]}

YOSHIDA, E ^{[1
]}

机构：

[1] FUKUSHIMA MED SCH,DEPT NEUROPSYCHIAT,FUKUSHIMA 96012,JAPAN

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 01期

关键词：

ESR-CT; L-BAND ESR; RAT HEAD; NITROXIDE;

D O I：

10.1016/0730-725X(92)90379-E

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Three-dimensional ESR imaging of a living rat has been performed by an L-band ESR system, which is composed of an L-band ESR spectrometer, a field gradient coil, and a data processor. The imaging was carried out by Lauterbur's method. A nitroxide, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (Carbamoyl-PROXYL), was used as an imaging agent in saline solution at a concentration of 0.2 M and administered intraperitoneally to obtain a constant concentration in the head for about an hour. It took about 40 min to obtain one set of ESR-CT images. The cross-sectional images were made, both as coronal and horizontal images. In the images of the rat head the nitroxide-rich region was clearly distinguished from the deficient region. The nitroxide-deficient areas corresponded well to the brain of the rat.

引用

页码：109 / 114

页数：6

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