ANDROSTENEDIONE AS A PREDICTOR OF OVARIAN HYPERSTIMULATION SYNDROME

被引：11

作者：

GUSTAFSON, O

CARLSTROM, K

NYLUND, L

机构：

[1] Department of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 07期

关键词：

ANDROSTENEDIONE; GNRHA; OVARIAN HYPERSTIMULATION SYNDROME; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

D O I：

10.1093/oxfordjournals.humrep.a137770

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Serum concentrations of testosterone, 4-androstene-3,17-dione (androstenedione), dehydroepiandrosterone (DHA) and its sulphate and sex hormone-binding globulin (SHBG) were measured in 30 ovulatory women before and after down-regulation with gonadotrophin releasing-hormone analogue, prior to ovarian stimulation in a programme of in-vitro fertilization and embryo transfer. Nine of the women developed ovarian hyperstimulation syndrome (OHSS) while the others did not. Pretreatment values of androstenedione and the androstenedione:DHA ratios were higher and the testosterone:androstenedione ratios lower in the OHSS women. The decrease in androstenedione levels during down-regulation was greater and the absolute levels following down-regulation were lower in the OHSS group. Higher levels of SHBG and lower testosterone:SHBG ratios, an index of biologically active testosterone, were observed in the OHSS group. The isolated elevation in pretreatment androstenedione levels and the high SHBG levels make the OHSS group different from patients with polycystic ovarian disease. Pretreatment values of testosterone:androstenedione or testosterone/SHBG:androstenedione ratios and/or the decrease in androstenedione during down-regulation may be used as markers, prior to stimulation, for identifying women at risk of developing OHSS.

引用

页码：918 / 921

页数：4

共 32 条

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