NADPH DIAPHORASE-POSITIVE CELLS IN THE BRAIN AFTER STATUS EPILEPTICUS

被引：15

作者：

LERNERNATOLI, M ^{[1
]}

DEBOCK, F ^{[1
]}

BOCKAERT, J ^{[1
]}

RONDOUIN, G ^{[1
]}

机构：

[1] CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,F-34094 MONTPELLIER,FRANCE

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

EPILEPSY; HIPPOCAMPUS; NITRIC OXIDE (NO); NITRIC OXIDE SYNTHASE (NOS); NEURONAL LOSS; GLIOSIS; MICROVASCULATURE;

D O I：

10.1097/00001756-199412000-00057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d-positive fibres in the periphery of degenerative pyramidal cells, the survival of NOS-containing interneurones in the dentate hilus, a different pattern of NADPH-d staining in lesioned areas, probably corresponding to the expression of inducible NOS by glial cells and an increased staining of the vasculature. These different sources of NO may exert different functions in the epileptic focus.

引用

页码：2633 / 2637

页数：5

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