FREE-RADICAL DNA ADDUCT 8-OH-DEOXYGUANOSINE AFFECTS ACTIVITY OF HPA-II AND MSP-I RESTRICTION ENDONUCLEASES

被引：20

作者：

TURK, PW

WEITZMAN, SA

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT MED,DIV HEMATOL ONCOL,CHICAGO,IL 60611

[2] NORTHWESTERN UNIV,SCH MED,ROBERT LURIE CANC CTR,CHICAGO,IL 60611

来源：

FREE RADICAL RESEARCH | 1995年 / 23卷 / 03期

关键词：

REACTIVE OXYGEN SPECIES; 8-OH-DEOXYGUANOSINE; 8-HYDROXYL-2'-DEOXYGUANOSINE; 8-HYDROXYGUANINE; RESTRICTION ENDONUCLEASE;

D O I：

10.3109/10715769509064038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

引用

页码：255 / 258

页数：4

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