ANTIHISTAMINES REDUCE BLOOD-RETINAL BARRIER PERMEABILITY IN TYPE-I (INSULIN-DEPENDENT) DIABETIC-PATIENTS WITH NONPROLIFERATIVE RETINOPATHY - A PILOT-STUDY

被引：31

作者：

GARDNER, TW

ELLER, AW

FRIBERG, TR

DANTONIO, JA

HOLLIS, TM

机构：

[1] Department of Ophthalmology, Penn State University College of Medicine, Hershey Medical Center, Hershey, PA

[2] Departments of Ophthalmology, Pittsburgh, PA

[3] Clinical Epidemiology and Preventive Medicine, The Eye and Ear Institute and University of Pittsburgh, Pittsburgh, PA

[4] Department of Biology, Penn State University, PA, University Park

[5] School of Health Sciences, Duquesne University, Pittsburgh

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1995年 / 15卷 / 02期

关键词：

ANTIHISTAMINES; BLOOD-RETINAL BARRIER PERMEABILITY; DIABETIC RETINOPATHY; HISTAMINE; HISTAMINE RECEPTORS; TYPE I (INSULIN-DEPENDENT) DIABETES;

D O I：

10.1097/00006982-199515020-00008

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine if histamine receptor stimulation mediates increased blood-retinal barrier (BRB) permeability in patients with diabetic retinopathy, as it does in experimental diabetes. Methods: Fourteen patients with type I (insulin-dependent) diabetes and mild nonproliferative diabetic retinopathy were treated with combined astemizole, 20 mg, and ranitidine, 600 mg, or an identical placebo for 6 months in a double-masked fashion, Blood-retinal barrier permeability was measured by vitreous fluorometry at baseline and at 3 and 6 months. Results: Permeability was significantly reduced in the group treated with antihistamines (P < 0.05) compared with the placebo group, There were no concomitant significant changes in systemic arterial blood pressure or HbA(1c) values. Conclusion: These pilot data suggest that histamine receptors influence permeability of the BRB in human diabetes. Further studies of the effects of antihistamines on diabetic retinopathy are warranted.

引用

页码：134 / 140

页数：7

共 37 条

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