CORRELATION OF DIFFERENTIATION-INDUCING ACTIVITY OF RETINOIDS ON HUMAN LEUKEMIA-CELL LINES HL-60 AND NB4

被引：39

作者：

HASHIMOTO, Y ^{[1
]}

KAGECHIKA, H ^{[1
]}

KAWACHI, E ^{[1
]}

FUKASAWA, H ^{[1
]}

SAITO, G ^{[1
]}

SHUDO, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1995年 / 121卷 / 11期

关键词：

RETINOID; LEUKEMIA; NB4; HL-60; DIFFERENTIATION;

D O I：

10.1007/BF01218530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Retinoids, including all-trans-retinoic acid, its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. A good linear correlation, with an r value of 0.91, between the ED(50) values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.

引用

页码：696 / 698

页数：3

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