ABSENCE OF ABNORMALITIES OF THE C-ERBB-1 AND C-ERBB-2 PROTOONCOGENES IN HUMAN THYROID NEOPLASIA

被引：57

作者：

LEMOINE, NR

WYLLIE, FS

LILLEHAUG, JR

STADDON, SL

HUGHES, CM

AASLAND, R

SHAW, J

VARHAUG, JE

BROWN, CL

GULLICK, WJ

WYNFORDTHOMAS, D

机构：

[1] UNIV COLL CARDIFF,DEPT PATHOL,CANC RES CTR,THYROID TUMOUR BIOL RES GRP,CARDIFF CF4 4XN,S GLAM,WALES

[2] UNIV BERGEN,DEPT BIOCHEM,BIOTECHNOL LAB,N-5014 BERGEN,NORWAY

[3] UNIV BERGEN,DEPT SURG,N-5014 BERGEN,NORWAY

[4] LONDON HOSP,INST PATHOL,DEPT MORBID ANAT,LONDON E1 1BB,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1990年 / 26卷 / 07期

关键词：

D O I：

10.1016/0277-5379(90)90149-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The c-erbB-1 and c-erbB-2 proto-oncogenes are frequently activated by gene amplification and overexpression in a variety of human cancers. In an analysis of a large series of benign and malignant thyroid tumours, no abnormalities of structure or expression of either of c-erbB-1 or c-erbB-2 were found. Activation of these oncogenes is not a necessary event in neoplasia of this epithelial system. © 1990.

引用

页码：777 / 779

页数：3

共 28 条

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