MELANIN-CONCENTRATING HORMONE - A STRUCTURAL AND CONFORMATIONAL STUDY BASED ON SYNTHESIS, BIOLOGICAL-ACTIVITY, HIGH-FIELD NMR, AND MOLECULAR MODELING TECHNIQUES

被引：12

作者：

BROWN, DW

CAMPBELL, MM

KINSMAN, RG

WHITE, PD

MOSS, CA

OSGUTHORPE, DJ

PAUL, PKC

BAKER, BI

机构：

[1] UNIV BATH,SCH BIOL SCI,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV BATH,MOLEC GRAPH UNIT,BATH BA2 7AY,AVON,ENGLAND

来源：

BIOPOLYMERS | 1990年 / 29卷 / 03期

关键词：

D O I：

10.1002/bip.360290314

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of Melanin‐concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5‐14 linear and 5‐14 cyclic, have been used as models for MCH— (Formula Presented.) in 1H‐nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：609 / 622

页数：14

共 19 条

[1] LOCALIZATION OF MELANIN-CONCENTRATING HORMONE-LIKE IMMUNOREACTIVITY IN THE BRAIN AND PITUITARY OF THE FROG RANA-RIDIBUNDA [J].