THE MPTP MODEL - VERSATILE CONTRIBUTIONS TO THE TREATMENT OF IDIOPATHIC PARKINSONS-DISEASE

被引：136

作者：

BLOEM, BR

IRWIN, I

BURUMA, OJS

HAAN, J

ROOS, RAC

TETRUD, JW

LANGSTON, JW

机构：

[1] CALIF PARKINSONS FDN, SAN JOSE, CA USA

[2] INST MED RES, SAN JOSE, CA 95128 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 97卷 / 2-3期

关键词：

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animal model; MPTP; Parkinson's disease; Parkinsonism; Pharmacotherapy; Transplantation;

D O I：

10.1016/0022-510X(90)90225-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In human and subhuman primates, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces irreversible clinical, biochemical and neuropathological alterations highly reminiscent of those observed in Parkinson's disease. The MPTP model has provided the best available tool to date for the assessment of efficacy and side-effects of symptomatic treatments of Parkinson's disease. In addition, the mechanism of action of MPTP has offered a basis for the development of novel therapeutic strategies aimed at the prevention of Parkinson's disease. © 1990.

引用

页码：273 / 293

页数：21

共 107 条

[1] BIOCHEMISTRY OF PARKINSONS-DISEASE 28 YEARS LATER - A CRITICAL-REVIEW [J].