HIGH-EFFICIENCY SYNTHESIS OF SIALYLOLIGOSACCHARIDES AND SIALOGLYCOPEPTIDES

被引：161

作者：

UNVERZAGT, C ^{[1
]}

KUNZ, H ^{[1
]}

PAULSON, JC ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOL CHEM,LOS ANGELES,CA 90024

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1990年 / 112卷 / 25期

关键词：

D O I：

10.1021/ja00181a037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sialyllactosamine structures were synthesized in high yield from carbohydrates and glycopeptides containing terminal GIcNAc with a two-step enzymatic glycosylation in a “one-pot” reaction. A key improvement is the use of alkaline phosphatase to destroy nucleotide phosphate inhibitors generated in the glycosyltransferase reaction. © 1990, American Chemical Society. All rights reserved.

引用

页码：9308 / 9309

页数：2

共 31 条

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