GASTRIC REFLEX RELAXATION BY COLONIC DISTENSION

被引:29
作者
BOJO, L
CASSUTO, J
机构
[1] CENT HOSP MOLNDAL,DEPT ANAESTHESIOL,MOLNDAL,SWEDEN
[2] GOTHENBURG UNIV,DEPT INTERNAL MED,S-41124 GOTHENBURG,SWEDEN
[3] GOTHENBURG UNIV,DEPT PHYSIOL,S-41124 GOTHENBURG,SWEDEN
来源
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1992年 / 38卷 / 01期
关键词
ATROPINE; COLON; GASTROINTESTINAL MOTILITY; HEXAMETHONIUM; RAT; STOMACH; VAGOTOMY; PRAZOSIN; YOHIMBINE; PROPANOLOL; NALOXONE;
D O I
10.1016/0165-1838(92)90216-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous studies in human volunteers have demonstrated an inhibition of gastric motility following painless rectal distension. In the present study we investigated, in anaesthetized rats, the effects of colonic distension on gastric tone and looked at certain aspects of the underlying nervous mechanisms. Changes in gastric volume were monitored continuously by a volumetric method. Colonic distension induced an immediate and pronounced gastric relaxation which lasted throughout the period of distension. The inhibition of gastric tone following colonic distension was abolished by hexamethonium or by bilateral cervical vagotomy. The selective adrenergic alpha-1 blocker, prazosin, the alpha-2 blocker, yohimbine, and the non-selective beta-blocker, propranolol, had no significant effect on gastric relaxation following colonic distension. Likewise, naloxone, an opioid receptor antagonist, did not significantly influence gastric reflex inhibition. It is concluded that colonic distension induced a non-adrenergic inhibition of gastric tone mediated through the vagal nerves. Ganglionic receptors are also suggested to form part of the inhibitory pathway.
引用
收藏
页码:57 / 64
页数:8
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