RADIOTHERAPY OF THE RHABDOMYOSARCOMA R1H OF THE RAT - RECOVERY FROM RADIATION-INJURY IN TUMOR AND SKIN

被引：9

作者：

WURSCHMIDT, F ^{[1
]}

BECKER, S ^{[1
]}

MAURER, T ^{[1
]}

OMNICZYNSKI, M ^{[1
]}

SCHELP, R ^{[1
]}

VOGLER, H ^{[1
]}

BECKBORNHOLDT, HP ^{[1
]}

机构：

[1] UNIV HAMBURG,INST BIOPHYS & RADIOBIOL,W-2000 HAMBURG 13,GERMANY

来源：

RADIOTHERAPY AND ONCOLOGY | 1992年 / 23卷 / 02期

关键词：

TUMOR; SKIN; IRRADIATION; FRACTIONATION; TWICE DAILY IRRADIATION; RECOVERY;

D O I：

10.1016/0167-8140(92)90341-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The response of the rhabdomyosarcoma R1H of the rat to fractionated irradiation has been reported to be almost independent of the dose per fraction in the range from 0.43 to 10 Gy. To elucidate whether recovery from radiation injury is impaired in fractionated irradiation or not, tumours were exposed on 5 days per week over 6 weeks either to a single daily dose or to two daily fractions separated by an interfraction interval of 2 h. Tumour response was assessed by net growth delay. Skin damage was scored for comparison. A significant reduction in tumour response (p < 0.009) and skin damage (p < 0.001) was observed when the daily dose was administered in a twice daily irradiation regimen, indicating that recovery from radiation injury does occur in the course of fractionated irradiation in our tumour system. As tumour response was almost independent of the dose per fraction for time intervals between fractions of at least 8 h, a possible explanation might be that recovery is compensated by improved reoxygenation.

引用

页码：105 / 110

页数：6

共 28 条

[1] EXPERIMENTAL RADIOTHERAPY OF A RAT RHABDOMYOSARCOMA WITH 15 MEV NEUTRONS AND 300 KV X-RAYS .2. EFFECTS OF FRACTIONATED TREATMENTS, APPLIED 5 TIMES A WEEK FOR SEVERAL WEEKS [J].

BARENDSEN, GW ;

BROERSE, JJ .

EUROPEAN JOURNAL OF CANCER, 1970, 6 (02) :89-+

[2] NET GROWTH DELAY - A NOVEL PARAMETER DERIVED FROM TUMOR-GROWTH CURVES [J].

BECKBORNHOLDT, HP ;

WURSCHMIDT, F ;

VOGLER, H .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (05) :773-777

[3] RADIOTHERAPY OF THE RHABDOMYOSARCOMA R1H OF THE RAT - HYPERFRACTIONATION - 126 FRACTIONS APPLIED WITHIN 6 WEEKS [J].

BECKBORNHOLDT, HP ;

MAURER, T ;

BECKER, S ;

OMNICZYNSKI, M ;

VOGLER, H ;

WURSCHMIDT, F .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1989, 16 (03) :701-705

[4] KINETICS OF CELLULAR INACTIVATION BY FRACTIONATED AND HYPERFRACTIONATED IRRADIATION IN LEWIS LUNG-CARCINOMA [J].

BECKBORNHOLDT, HP ;

PEACOCK, JH ;

STEPHENS, TC .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1985, 11 (06) :1171-1177

[5] POSSIBLE DOSE-RATE DEPENDENCE OF RECOVERY KINETICS AS DEDUCED FROM A PRELIMINARY-ANALYSIS OF THE EFFECTS OF FRACTIONATED IRRADIATIONS AT VARYING DOSE-RATES [J].

DALE, RG ;

HUCZKOWSKI, J ;

TROTT, KR .

BRITISH JOURNAL OF RADIOLOGY, 1988, 61 (722) :153-157

[6] THE EFFECT OF MULTIPLE SMALL DOSES OF X RAYS ON SKIN REACTIONS IN THE MOUSE AND A BASIC INTERPRETATION [J].

DOUGLAS, BG ;

FOWLER, JF .

RADIATION RESEARCH, 1976, 66 (02) :401-426

[7] RADIATION RESPONSE OF MAMMALIAN CELLS GROWN IN CULTURE .1. REPAIR OF X-RAY DAMAGE IN SURVIVING CHINESE HAMSTER CELLS [J].

ELKIND, MM ;

SUTTON, H .

RADIATION RESEARCH, 1960, 13 (04) :556-593

[8]

FOWLER JF, 1988, BRIT J RADIOL, V61, P704, DOI 10.1259/0007-1285-61-728-704

[9] EXPERIMENTS WITH FRACTIONATED X-RAY TREATMENT OF THE SKIN OF PIGS .1. FRACTIONATION UP TO 28 DAYS [J].

FOWLER, JF ;

MORGAN, RL ;

SILVESTER, JA ;

BEWLEY, DK ;

TURNER, BA .

BRITISH JOURNAL OF RADIOLOGY, 1963, 36 (423) :188-196

[10] RELATIVE EFFECTIVENESS OF 12-HOURLY FRACTIONATION AND A NONUNIFORM X-RAY SCHEDULE IN OPTIMUM FRACTIONATION OF C3H MOUSE MAMMARY-TUMORS [J].

FOWLER, JF ;

SHELDON, PW ;

HARRIS, SR ;

HILL, SA ;

AYRES, SE .

BRITISH JOURNAL OF RADIOLOGY, 1975, 48 (571) :581-589

← 1 2 3 →