GLUTAMATE RECEPTORS OF DROSOPHILA-MELANOGASTER - PRIMARY STRUCTURE OF A PUTATIVE NMDA RECEPTOR PROTEIN EXPRESSED IN THE HEAD OF THE ADULT FLY

被引：80

作者：

ULTSCH, A ^{[1
]}

SCHUSTER, CM ^{[1
]}

LAUBE, B ^{[1
]}

BETZ, H ^{[1
]}

SCHMITT, B ^{[1
]}

机构：

[1] MAX PLANCK INST HIRNFORSCH, NEUROCHEM ABT, DEUTSCHORDENSTR 46, W-6000 FRANKFURT 71, GERMANY

来源：

FEBS LETTERS | 1993年 / 324卷 / 02期

关键词：

GLUTAMATE RECEPTOR; NMDA RECEPTOR HOMOLOG; DROSOPHILA-MELANOGASTER;

D O I：

10.1016/0014-5793(93)81387-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NMDA subtype of ionotropic glutamate receptors has been implicated in the activity-dependent modification of synaptic efficacy in the mammalian brain. Here we describe a cDNA isolated from Drosophila melanogaster which encodes a putative invertebrate NMDA receptor protein (DNMDAR-I). The deduced amino acid sequence of DNMDAR-I displays 46% amino acid identity to the rat NMDAR1 polypeptide and shows significant homology (16-23%) to other vertebrate and invertebrate glutamate receptor proteins. The DNMDAR-I gene maps to position 83AB of chromosome 3R and is highly expressed in the head of adult flies. Our data indicate that the NMDA subtype of glutamate receptors evolved early during phylogeny and suggest the existence of activity-dependent synaptic plasticity in the insect brain.

引用

页码：171 / 177

页数：7

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