RAPID AND SENSITIVE PRECOLUMN EXTRACTION HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR PROPOFOL IN BIOLOGICAL-FLUIDS

被引：16

作者：

ALTMAYER, P ^{[1
]}

BUCH, U ^{[1
]}

BUCH, HP ^{[1
]}

LARSEN, R ^{[1
]}

机构：

[1] UNIV SAARLAND,INST PHARMACOL & TOXIKOL,W-6650 HOMBURG,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 612卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80181-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A completely automated high-performance liquid chromatographic system is described for the determination of the phenolic anaesthetic propofol. The method is based on pre-column extraction in a closed system allowing direct injection of biological samples without any sample pretreatment. The assay is sensitive (limit of quantification is 5 ng/ml serum), reliable (the variability within a series is 2%) and rapid (results are available after 6 min).

引用

页码：326 / 330

页数：5

共 4 条

[1]

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[4] FULLY AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - A NEW CHROMATOGRAPH FOR PHARMACOKINETIC DRUG-MONITORING BY DIRECT INJECTION OF BODY-FLUIDS [J].

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