PSEUDORABIES VIRUS EARLY PROTEIN-0 TRANSACTIVATES THE VIRAL GENE PROMOTERS

被引：33

作者：

WATANABE, S

ONO, E

SHIMIZU, Y

KIDA, H

机构：

[1] HOKKAIDO UNIV, GRAD SCH VET MED, DEPT DISEASE CONTROL, MICROBIOL LAB, SAPPORO, HOKKAIDO 060, JAPAN

[2] HOKKAIDO UNIV, INST IMMUNOL SCI, ANIM EXPT LAB, SAPPORO, HOKKAIDO 060, JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1995年 / 76卷

关键词：

D O I：

10.1099/0022-1317-76-11-2881

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pseudorabies virus (PRV) early protein O (EPO) contains the RING finger domain with homology to the immediate-early (IE) protein ICPO of herpes simplex virus type 1 (HSV-1). EPO was detected by indirect immunofluorescence in the nuclei of the cells transfected with EPO expression plasmid as is the case in cells infected with PRV. In transient expression assays, EPO transactivated the PRV IE, thymidine kinase (TK) and glycoprotein X (gX) promoters, indicating that EPO, like ICPO of HSV-1, is a transactivating protein.

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页码：2881 / 2885

页数：5

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