DISCODERMOLIDE - A NEW BIOACTIVE POLYHYDROXYLATED LACTONE FROM THE MARINE SPONGE DISCODERMIA-DISSOLUTA

被引：342

作者：

GUNASEKERA, SP ^{[1
]}

GUNASEKERA, M ^{[1
]}

LONGLEY, RE ^{[1
]}

SCHULTE, GK ^{[1
]}

机构：

[1] YALE UNIV,CTR CHEM INSTRUMENTAT,DEPT CHEM,NEW HAVEN,CT 06511

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 16期

关键词：

D O I：

10.1021/jo00303a029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new polyhydroxylated lactone, discodermolide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy, and verified by X-ray crystallographic analysis. The carbon skeleton displayed by discodermolide is new; discodermolide is immunosuppressive and cytotoxic. © 1990, American Chemical Society. All rights reserved.

引用

页码：4912 / 4915

页数：4

共 14 条

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