MECHANISM OF CYTOCHROME-P-450 CATALYSIS - MECHANISM OF N-DEALKYLATION AND AMINE OXIDE DEOXYGENATION

被引：109

作者：

BURKA, LT

GUENGERICH, FP

WILLARD, RJ

MACDONALD, TL

机构：

[1] VANDERBILT UNIV,DEPT BIOCHEM,NASHVILLE,TN 37232

[2] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1985年 / 107卷 / 08期

关键词：

D O I：

10.1021/ja00294a057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：2549 / 2551

页数：3

共 24 条

[1] ISOTOPE-EFFECTS IN ENZYMATIC N-DEMETHYLATION OF TERTIARY-AMINES
ABDELMONEM, MM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (04) : 427 - 430
[2] AUGUSTO O, 1982, J BIOL CHEM, V257, P1288
[3] ENZYMATIC MONOOXYGENATION OF HALOGEN ATOMS - CYTOCHROME-P-450 CATALYZED OXIDATION OF IODOBENZENE BY IODOSOBENZENE
BURKA, LT
THORSEN, A
GUENGERICH, FP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (25) : 7615 - 7616
[4] COCHIN J, 1959, J PHARMACOL EXP THER, V125, P105
[5] GROVES JT, 1980, J AM CHEM SOC, V102, P6377
[6] PURIFICATION AND CHARACTERIZATION OF LIVER MICROSOMAL CYTOCHROMES-P-450 - ELECTROPHORETIC, SPECTRAL, CATALYTIC, AND IMMUNOCHEMICAL PROPERTIES AND INDUCIBILITY OF 8 ISOZYMES ISOLATED FROM RATS TREATED WITH PHENOBARBITAL OR BETA-NAPHTHOFLAVONE
GUENGERICH, FP
DANNAN, GA
WRIGHT, ST
MARTIN, MV
KAMINSKY, LS
[J]. BIOCHEMISTRY, 1982, 21 (23) : 6019 - 6030
[7] CHEMICAL MECHANISMS OF CATALYSIS BY CYTOCHROMES-P-450 - A UNIFIED VIEW
GUENGERICH, FP
MACDONALD, TL
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1984, 17 (01) : 9 - 16
[8] GUENGERICH FP, 1984, J MED CHEM, V27, P1103
[9] SUICIDAL INACTIVATION OF CYTOCHROME-P-450 BY CYCLOPROPYLAMINES - EVIDENCE FOR CATION-RADICAL INTERMEDIATES
HANZLIK, RP
TULLMAN, RH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (07) : 2048 - 2050
[10] DEMETHYLATION OF N,N-DIMETHYLANILINE AND P-CYANO-N,N-DIMETHYLANILINE AND THEIR N-OXIDES BY CYTOCHROMES P450LM2 AND P450CAM
HEIMBROOK, DC
MURRAY, RI
EGEBERG, KD
SLIGAR, SG
NEE, MW
BRUICE, TC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) : 1514 - 1515

← 1 2 3 →