MOLECULAR MAPPING OF THE MOUSE OB MUTATION

被引：144

作者：

FRIEDMAN, JM ^{[1
]}

LEIBEL, RL ^{[1
]}

SIEGEL, DS ^{[1
]}

WALSH, J ^{[1
]}

BAHARY, N ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,HUMAN BEH & METAB LAB,NEW YORK,NY 10021

来源：

GENOMICS | 1991年 / 11卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90032-A

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mouse ob mutation has been mapped relative to a series of RFLPs among the progeny of three separate mouse crosses: an intraspecific backcross, an intraspecific intercross, and an interspecific intercross. Genotypic assignment at the ob locus was made by making use of measurements of body mass index and the plasma concentrations of glucose and insulin. These data have suggested that the development of diabetes in these animals is a consequence of unlinked polygenes. There was also evidence that unlinked Mus spretus alleles can diminish the obesity of ob obmice. From these data we have mapped several markers on chromosome 6 with the following order: cen-Cola-2-Met-ob-Cpa-Tcrb. The homologs of markers that flank ob map to human chromosome 7q, suggesting that if there is a human homologue of ob, it maps to 7q31. © 1991.

引用

页码：1054 / 1062

页数：9

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