THE VACCINIA VIRUS HINDIII-F FRAGMENT - NUCLEOTIDE-SEQUENCE OF THE LEFT 6.2 KB

被引：18

作者：

ROSEMAN, NA

SLABAUGH, MB

机构：

[1] Department of Biochemistry and Biophysics, Center for Gene Research and Biotechnology, Oregon State University, Corvallis

来源：

VIROLOGY | 1990年 / 178卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90338-R

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of the left 6.2 kb of the 13.2-kb HindIII F fragment of vaccinia virus was determined. Translation of the sequence revealed nine closely spaced, tandemly oriented open reading frames (ORFs), all reading leftward. the transcriptional organization of this region was determined by Northern blot and S1 nuclease mapping. The analysis suggested that ORFs 1, 2, 4, 5, 6, 7, and 8 are transcribed early in infection, whereas ORFs 3 and 9 are probably late genes. Two of these ORFs have been reported previously. ORF F4L encodes the small subunit of ribonucleotide reductase and ORF F2L is homologous to a retroviral protease-like gene. © 1990.

引用

页码：410 / 418

页数：9

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