MODIFYING EFFECTS OF PREEXISTING PULMONARY FIBROSIS ON BIOLOGICAL RESPONSES OF RATS TO INHALED PUO2(PU-239)

被引：15

作者：

LUNDGREN, DL

MAUDERLY, JL

REBAR, AH

GILLETT, NA

HAHN, FF

机构：

[1] Lovelace ITRI, Albuquerque, NM, 87185-5890

[2] Office of Research Development, College of Veterinary Medicine, Purdue University, Lafayette, IN

[3] Genentech Inc., South San Francisco, CA, 94080

[4] Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, 87185

来源：

HEALTH PHYSICS | 1991年 / 60卷 / 03期

关键词：

D O I：

10.1097/00004032-199103000-00004

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We investigated the modifying effects of preexisting, bleomycin-induced pulmonary fibrosis on the deposition, retention, and biological effects of inhaled (PuO2)-Pu-239 in the rat. Among rats exposed to similar airborne concentrations of (PuO2)-Pu-239, initial lung burdens of Pu-239 per kilogram body mass were similar whether or not pulmonary fibrosis was present. However, clearance of Pu-239 from the lungs was significantly decreased in the rats with preexisting pulmonary fibrosis. The incidence of lung lesions (epithelial hyperplasia, diffuse macrophage increases and aggregation, and loose and dense connective tissue) was significantly greater among rats with preexisting pulmonary fibrosis than among the exposed controls. Rats with preexisting fibrosis had shorter life spans than (PuO2)-Pu-239-exposed control rats. When groups of rats with similar alpha-doses to the lungs were compared, the incidences of neoplastic lesions in the lung, the times to death of rats with lung neoplasms, and the risk of lung tumors per unit of alpha-dose to the lungs in rats with or without pulmonary fibrosis were similar. The results of this study suggest that humans with uncomplicated pulmonary fibrosis may not be more sensitive to the carcinogenic effects of inhaled (PuO2)-Pu-239 than are individuals with normal lungs, assuming that the total alpha-doses to the lungs are similar.

引用

页码：353 / 363

页数：11

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