SYNTHETIC INVESTIGATIONS OF RAPAMYCIN .1. SYNTHESIS OF A C10-C21 FRAGMENT

被引：36

作者：

MEYER, SD ^{[1
]}

MIWA, T ^{[1
]}

NAKATSUKA, M ^{[1
]}

SCHREIBER, SL ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 19期

关键词：

D O I：

10.1021/jo00045a007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphine oxide 2, representing the C-10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Homer-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.

引用

页码：5058 / 5060

页数：3

共 31 条

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