PREPARATION OF [I-131] IODINATED NONOXYNOL-9

被引：5

作者：

AGHA, BJ ^{[1
]}

GARBOLAS, GA ^{[1
]}

WETS, K ^{[1
]}

DIGENIS, GA ^{[1
]}

机构：

[1] UNIV KENTUCKY, COLL PHARM, DIV MED CHEM & PHARMACOGNOSY, LEXINGTON, KY 40536 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1984年 / 21卷 / 09期

关键词：

D O I：

10.1002/jlcr.2580210906

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel method for the radioiodination [131I] of the multicomponent non-ionic surfactant nonoxynol-9 (N-9) [the most widely used non-ionic surfactant in vaginal spermicides] is described. The extent of incorporation and distribution of the 131I-label into the aromatic moiety of various ethoxymer units of N-9 was determined utilizing a high pressure liquid chromatography (HPLC) method.

引用

页码：821 / 831

页数：11

共 9 条

[1]

AGHA B, UNPUB

[2]

AHERN J, COMMUNICATION

[3] A SIMPLIFIED HIGH-PRESSURE LIQUID-CHROMATOGRAPHY METHOD FOR DETERMINING LIPOPHILICITY FOR STRUCTURE ACTIVITY RELATIONSHIPS [J].

BRENT, DA ;

SABATKA, JJ ;

MINICK, DJ ;

HENRY, DW .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (07) :1014-1020

[4]

BUTTAR HS, 1982, TOXICOL LETT, V13, P211

[5] STUDIES ON NONOXYNOL-9 .2. INTRA-VAGINAL ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION IN RATS AND RABBITS [J].

CHVAPIL, M ;

ESKELSON, CD ;

STIFFEL, V ;

OWEN, JA ;

DROEGEMUELLER, W .

CONTRACEPTION, 1980, 22 (03) :325-339

[6]

CHVAPIL M, 1979, VAGINAL CONTRACEPTIO, P165

[7]

DIGENIS G, 1980, RES FRONTIERS FERTIL, P23

[8] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINING ETHOXYMER DISTRIBUTION OF ALKYLPHENOXY POLYOXYETHYLENE SURFACTANTS [J].

ROTHMAN, AM .

JOURNAL OF CHROMATOGRAPHY, 1982, 253 (02) :283-288

[9]

Taylor E.C., 1970, J AM CHEM SOC, V92, P2175

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