RE-186(SN) HEDP FOR TREATMENT OF PAINFUL OSSEOUS METASTASES - INITIAL CLINICAL-EXPERIENCE IN 20 PATIENTS WITH HORMONE-RESISTANT PROSTATE-CANCER

被引：139

作者：

MAXON, HR

SCHRODER, LE

THOMAS, SR

HERTZBERG, VS

DEUTSCH, EA

SCHER, HI

SAMARATUNGA, RC

LIBSON, KF

WILLIAMS, CC

MOULTON, JS

SCHNEIDER, HJ

机构：

[1] UNIV CINCINNATI,MED CTR,DIV MED PHYS,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,MED CTR,DIV DIAGNOST RADIOL,CINCINNATI,OH 45267

[3] UNIV CINCINNATI,MED CTR,DEPT INTERNAL MED,DIV HEMATOL ONCOL,CINCINNATI,OH 45267

[4] UNIV CINCINNATI,MED CTR,DEPT ENVIRONM HLTH,DIV EPIDEMIOL & BIOSTAT,CINCINNATI,OH 45267

[5] UNIV CINCINNATI,MED CTR,DEPT CHEM,BIODYNAM RES CTR,CINCINNATI,OH 45267

[6] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021

来源：

RADIOLOGY | 1990年 / 176卷 / 01期

关键词：

Bone neoplasms, secondary, 30.33,40.33; Bone neoplasms; therapeutic radiology; 40.1299; Prostate; neoplasms; 844.32; Radionuclides; therapeutic;

D O I：

10.1148/radiology.176.1.1693784

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Rhenium-186(tin) hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in areas of osseous metastases in a manner similar to that of standard bone-scanning agents. It also emits beta particles with sufficient energy to be therapeutically useful. A single intravenous injection of about 33mCi (1,221 MBq) was given to each of 20 elderly patients with advanced skeletal metastases from honnonally resistant prostate cancer. Prompt, significant relief of pain occurred 80% of the time with no significant side effects and only minimal, transient marrow toxicity. Re-186(Sn) HEDP appears to be a useful new agent for the palliation of painful osseous metastases in prostate cancer.

引用

页码：155 / 159

页数：5

共 23 条

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