CELL VACUOLIZATION INDUCED BY HELICOBACTER-PYLORI - INHIBITION BY BAFILOMYCIN-A1, BAFILOMYCIN-B1, BAFILOMYCIN-C1 AND BAFILOMYCIN-D

被引:28
作者
PAPINI, E
DEBERNARD, M
BUGNOLI, M
MILIA, E
RAPPUOLI, R
MONTECUCCO, C
机构
[1] UNIV PADUA,DIPARTIMENTO SCI BIOMED,VIA TRIESTE 75,I-35121 PADUA,ITALY
[2] IST RIC IMMUNOBIOL SIENA,I-53100 SIENA,ITALY
关键词
HELICOBACTER-PYLORI; CELL VACUOLATION; CYTOTOXIN; BAFILOMYCINS; VACUOLAR ATPASE;
D O I
10.1016/0378-1097(93)90262-Z
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
All available bafilomycins (A1, B1, C1 and D) inhibit and revert macroscopic vacuolization induced by Helicobacter pylori cell-free extracts. Bafilomycin A1 displays the highest activity, followed by bafilomycin B1, C1 and D. The different potency of bafilomycins correlates with their ability to inhibit the vacuolar-type ATPase (V-ATPase) and to dissipate the membrane pH gradient of intracellular acidic organelles. These results suggest that bafilomycins should be considered as possible therapeutic agents in the treatment of gastritis.
引用
收藏
页码:155 / 160
页数:6
相关论文
共 19 条
[1]   UPTAKE OF DYES AND DRUGS BY LIVING CELLS IN CULTURE [J].
ALLISON, AC ;
YOUNG, MR .
LIFE SCIENCES, 1964, 3 (12) :1407-1414
[2]   HELICOBACTER-PYLORI AND THE PATHOGENESIS OF GASTRODUODENAL INFLAMMATION [J].
BLASER, MJ .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (04) :626-633
[3]   BAFILOMYCINS - A CLASS OF INHIBITORS OF MEMBRANE ATPASES FROM MICROORGANISMS, ANIMAL-CELLS, AND PLANT-CELLS [J].
BOWMAN, EJ ;
SIEBERS, A ;
ALTENDORF, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :7972-7976
[4]  
CORREA P, 1992, CANCER RES, V52, P6735
[5]   EFFECT OF UREASE ON HELA-CELL VACUOLATION INDUCED BY HELICOBACTER-PYLORI CYTOTOXIN [J].
COVER, TL ;
PURYEAR, W ;
PEREZPEREZ, GI ;
BLASER, MJ .
INFECTION AND IMMUNITY, 1991, 59 (04) :1264-1270
[6]  
COVER TL, 1992, J BIOL CHEM, V267, P10570
[7]   CHARACTERIZATION OF AND HUMAN SEROLOGIC RESPONSE TO PROTEINS IN HELICOBACTER-PYLORI BROTH CULTURE SUPERNATANTS WITH VACUOLIZING CYTOTOXIN ACTIVITY [J].
COVER, TL ;
DOOLEY, CP ;
BLASER, MJ .
INFECTION AND IMMUNITY, 1990, 58 (03) :603-610
[8]   EVIDENCE FOR AN ATP-DRIVEN PROTON PUMP IN RAT-LIVER LYSOSOMES BY BASIC-DYES UPTAKE [J].
DELLANTONE, P .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 86 (01) :180-189
[9]   CYTO-TOXIN PRODUCTION BY CAMPYLOBACTER-PYLORI STRAINS ISOLATED FROM PATIENTS WITH PEPTIC-ULCERS AND FROM PATIENTS WITH CHRONIC GASTRITIS ONLY [J].
FIGURA, N ;
GUGLIELMETTI, P ;
ROSSOLINI, A ;
BARBERI, A ;
CUSI, G ;
MUSMANNO, RA ;
RUSSI, M ;
QUARANTA, S .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (01) :225-226
[10]  
FIGURA N, 1990, HELICOBACTER PYLORI, P86, DOI DOI 10.1007/978-3-642-75315-2_13