MEMBRANE-ASSOCIATED GTPASES IN BACTERIA

被引：48

作者：

MARCH, PE

机构：

[1] Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Weed Johnson Medical School, Piscataway, New Jersey

来源：

MOLECULAR MICROBIOLOGY | 1992年 / 6卷 / 10期

关键词：

D O I：

10.1111/j.1365-2958.1992.tb00845.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the GTPase superfamily are extremely important in regulating membrane signalling pathways in all cells. This review focuses on membrane-associated GTPases that have been described in prokaryotes. In bacteria, LepA and NodQ are very similar to protein synthesis elongation factors but apparently have membrane-related functions. The amino acid sequences of FtsY and Ffh are clearly related to eukaryotic factors involved in protein secretion. Obg and Era are not closely related to any GTPase subgroup according to amino acid sequence comparisons, but they are essential for viability. In spite of similarities to well-studied eukaryotic proteins the signalling pathways of these cellular regulators, with the exception of NodQ, have not yet been elucidated.

引用

页码：1253 / 1257

页数：5

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