URINARY TRANSFERRIN EXCRETION IN TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS

被引：19

作者：

ODONNELL, MJ ^{[1
]}

MARTIN, P ^{[1
]}

FLORKOWSKI, CM ^{[1
]}

TOOP, MJ ^{[1
]}

CHAPMAN, C ^{[1
]}

HOLDER, R ^{[1
]}

BARNETT, AH ^{[1
]}

机构：

[1] E BIRMINGHAM DIST GEN HOSP,UNDERGRAD TEACHING CTR,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 07期

关键词：

DIABETES-MELLITUS; NEPHROPATHY; PROTEINURIA; ALBUMIN; TRANSFERRIN; TRANSFERRINURIA;

D O I：

10.1111/j.1464-5491.1991.tb01673.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Urinary excretion of transferrin and albumin was studied by radioimmunoassay in 47 adult patients with Type 1 diabetes and 28 control subjects. Median (range) urinary transferrin excretion rate was significantly elevated in the diabetic group 0.58 (0.02-2663.3)-mu-g min-1 compared with the control group 0.04 (0.01-0.28)-mu-g min-1, p < 0.001. Urinary transferrin:creatinine ratios (x 10(2)) were different in diabetic 47 (0.6-958.0)-mu-g mmol-1 and control groups 0.7 (0.06-2.3)-mu-g mmol-1, p < 0.001. There were correlations between urinary transferrin and albumin excretion rates in diabetic (r = 0.78, p < 0.001) and control groups (r = 0.81, p < 0.05). Forty (85 %) diabetic patients had elevated transferrin excretion rates, 18 (38.3 %) had elevated albumin excretion rates. All diabetic patients with elevated albumin excretion rates had elevated transferrin excretion rates. Twenty-one (77.8 %) of the patients with normal albumin excretion rates had elevated transferrin excretion rates. Urinary excretion of N-acetyl-beta-D-glucosaminidase was greater in diabetic patients than control subjects (142 vs 58-mu-mol h-1 l-1, p < 0.001). There were correlations between transferrin and N-acetyl-beta-D-glucosaminidase excretion (r = 0.67, p < 0.01) and albumin and N-acetyl-beta-D-glucosaminidase excretion (r = 0.63, p < 0.01) in the diabetic group. Elevated urinary transferrin excretion rate may be a marker for renal dysfunction in diabetes mellitus.

引用

页码：657 / 661

页数：5

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