HIGHLY STEREOCONTROLLED AND CONCISE ASYMMETRIC-SYNTHESIS OF THE BETA-LACTAM FRAMEWORK VIA A TCC METHOD

被引：8

作者：

ASAO, N ^{[1
]}

SHIMADA, T ^{[1
]}

TSUKADA, N ^{[1
]}

YAMAMOTO, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)74424-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conjugate addition of LSA 1 to t-butyl (4S)4-(trilyl)oxy-2-pentenoate 2d followed by aldol condensation with acetaldehyde produces a key intermediate 3 to beta-lactam derivatives as a single diastereoisomer in 77% yield.

引用

页码：8425 / 8428

页数：4

共 22 条

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