EFFECTS OF AMP ON POTENTIAL OF RAT CEREBRAL CORTICAL-NEURONS

被引：24

作者：

EDSTROM, JP ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] UNIV SASKATCHEWAN, COLL MED, DEPT PHYSIOL, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1976年 / 54卷 / 05期

关键词：

D O I：

10.1139/y76-110

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracellular recordings showed that AMP, applied extracellularly, consistently produced a hyperpolarization in the absence of any pronounced alterations in membrane conductance and caused a reduction in spontaneoulsy occurring and evoked postsynaptic potentials. Potential mechanisms of action of AMP were discussed, including the possibility that it may depress transmitter release from presynaptic nerve terminals.

引用

页码：787 / 790

页数：4

共 14 条

[1]

BURNSTOCK G, 1972, PHARMACOL REV, V24, P509

[2] EFFECT OF ADENOSINE ON RELEASE OF TRANSMITTER FROM PHRENIC NERVE OF RAT [J].

GINSBORG, BL ;

HIRST, GDS .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 224 (03) :629-&

[3] THE LIBERATION OF ADENOSINE TRIPHOSPHATE ON ANTIDROMIC STIMULATION OF SENSORY NERVES [J].

HOLTON, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1959, 145 (03) :494-504

[4] ABSENCE OF ADENINE-NUCLEOTIDE RELEASE FROM AUTONOMIC GANGLION [J].

KATO, AC ;

KATZ, HS ;

COLLIER, B .

NATURE, 1974, 249 (5457) :576-577

[5] ACTION OF GAMMA-AMINOBUTYRIC ACID ON CORTICAL NEURONES [J].

KRNJEVIC, K ;

SCHWARTZ, S .

EXPERIMENTAL BRAIN RESEARCH, 1967, 3 (04) :320-&

[6] CYCLIC NUCLEOTIDES IN SPINAL CELLS [J].

KRNJEVIC, K ;

VANMETER, WG .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1976, 54 (03) :416-421

[7] UPTAKE AND RELEASE OF [C-14]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEM [J].

KURODA, Y ;

MCILWAIN, H .

JOURNAL OF NEUROCHEMISTRY, 1974, 22 (05) :691-699

[8] SIMPLE RAPID METHOD FOR PREPARING PARALLEL MICROPIPETTE ELECTRODES [J].

OLIVER, AP .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1971, 31 (03) :284-&

[9] ADENOSINE AS A PUTATIVE TRANSMITTER IN CEREBRAL-CORTEX - STUDIES WITH POTENTIATORS AND ANTAGONISTS [J].

PHILLIS, JW ;

KOSTOPOULOS, GK .

LIFE SCIENCES, 1975, 17 (07) :1085-1094

[10] DEPRESSION OF CORTICOSPINAL CELLS BY VARIOUS PURINES AND PYRIMIDINES [J].

PHILLIS, JW ;

KOSTOPOULOS, GK ;

LIMACHER, JJ .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1974, 52 (06) :1226-1229

← 1 2 →