NEPHROTOXICITY AND HEPATOTOXICITY OF 1,1-DICHLORO-2,2-DIFLUOROETHYLENE IN THE RAT - INDICATIONS FOR DIFFERENTIAL MECHANISMS OF BIOACTIVATION

被引：50

作者：

COMMANDEUR, JNM ^{[1
]}

OOSTENDORP, RAJ ^{[1
]}

SCHOOFS, PR ^{[1
]}

XU, B ^{[1
]}

VERMEULEN, NPE ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM,DEPT PHARMACOCHEM MOLEC TOXICOL,DE BOELELAAN 1083,1081 HV AMSTERDAM,NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1987年 / 36卷 / 24期

关键词：

D O I：

10.1016/0006-2952(87)90663-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

收藏

页码：4229 / 4237

页数：9

相关论文

共 30 条

[1] SATURABLE METABOLISM AND THE ACUTE TOXICITY OF 1,1-DICHLOROETHYLENE
ANDERSEN, ME
FRENCH, JE
GARGAS, ML
JONES, RA
JENKINS, LJ
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1979, 47 (02) : 385 - 393
[2] Arndt F., 1943, ORG SYNTH, VII, P165
[3] TOXICOLOGY OF FLUOROALKENES - REVIEW AND RESEARCH NEEDS
CLAYTON, JW
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1977, 21 (DEC) : 255 - 267
[4] NOVEL METABOLITES OF TRICHLOROETHYLENE THROUGH DECHLORINATION REACTIONS IN RATS, MICE AND HUMANS
DEKANT, W
METZLER, M
HENSCHLER, D
[J]. BIOCHEMICAL PHARMACOLOGY, 1984, 33 (13) : 2021 - 2027
[5] IDENTIFICATION OF S-1,2-DICHLOROVINYL-N-ACETYL-CYSTEINE AS A URINARY METABOLITE OF TRICHLOROETHYLENE - A POSSIBLE EXPLANATION FOR ITS NEPHROCARCINOGENICITY IN MALE-RATS
DEKANT, W
METZLER, M
HENSCHLER, D
[J]. BIOCHEMICAL PHARMACOLOGY, 1986, 35 (15) : 2455 - 2458
[6] DOHN DR, 1985, J PHARMACOL EXP THER, V235, P851
[7] RENAL PROCESSING OF GLUTATHIONE CONJUGATES - ROLE IN NEPHROTOXICITY
ELFARRA, AA
ANDERS, MW
[J]. BIOCHEMICAL PHARMACOLOGY, 1984, 33 (23) : 3729 - 3732
[8] ELFARRA AA, 1985, J PHARMACOL EXP THER, V233, P512
[9] MECHANISM OF S-(1,2-DICHLOROVINYL)GLUTATHIONE-INDUCED NEPHROTOXICITY
ELFARRA, AA
JAKOBSON, I
ANDERS, MW
[J]. BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) : 283 - 288
[10] SPECIES-DIFFERENCES IN RESPONSE TO TRICHLOROETHYLENE .2. BIOTRANSFORMATION IN RATS AND MICE
GREEN, T
PROUT, MS
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1985, 79 (03) : 401 - 411