AN IDIOTYPIC NETWORK MODEL OF AIDS IMMUNOPATHOGENESIS

被引：100

作者：

HOFFMANN, GW ^{[1
]}

KION, TA ^{[1
]}

GRANT, MD ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PHYS,VANCOUVER V6T 1W5,BC,CANADA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 08期

关键词：

D O I：

10.1073/pnas.88.8.3060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Considerations from a network theory of the immune system suggest that human immunodeficiency virus and allogeneic stimuli may act synergistically to cause AIDS. The immune responses to these stimuli include two components that are directed against each other. In some AIDS risk groups other antigens that mimic major histocompatibility complex antigens may substitute for allogeneic stimuli. Implications for the prevention of AIDS are discussed.

引用

页码：3060 / 3064

页数：5

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