THE FUTURE OF GENETIC EPIDEMIOLOGY

被引：14

作者：

MORTON, NE

机构：

[1] The Princess Anne Hospital, Southampton

来源：

ANNALS OF MEDICINE | 1992年 / 24卷 / 06期

关键词：

GENETIC EPIDEMIOLOGY; SEGREGATION; LINKAGE; MAP; COUNSELING; AMPLIFICATION;

D O I：

10.3109/07853899209167010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Starting from a broad definition of genetic epidemiology, current developments in association, segregation, and linkage analysis of complex inheritance are considered together with integration of genetic and physical maps and resolution of genetic heterogeneity. Mitochondrial inheritance, imprinting, uniparental disomy, pregressive amplification, and gonadal mosaicism are some of the novel mechanisms discussed, with speculation about the future of genetic epidemiology.

引用

页码：557 / 562

页数：6

共 47 条

[1]

BERG K, 1987, CIBA F SYMP, V130, P14

[2] REGRESSIVE LOGISTIC-MODELS FOR FAMILIAL DISEASE AND OTHER BINARY TRAITS [J].