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TOXIC EFFECT OF INTRAVENTRICULAR INTERFERON-ALPHA IN SUBACUTE SCLEROSING PANENCEPHALITIS

被引：7
作者：
CIANCHETTI, C
FRATTA, AL
MUNTONI, F
MARROSU, G
MARROSU, MG
机构：
[1] Clinica di Neuropsichiatria Infantile, Università di Cagliari, Via Ospedale 119, Cagliari
来源：
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1994年 / 15卷 / 03期
关键词：
SUBACUTE SCLEROSING PANENCEPHALITIS; INTERFERON-ALPHA; TOXIC EFFECT;
D O I：
10.1007/BF02339207
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Intraventricular interferon (IFN) administration has been shown to improve the course of SSPE. However, in 2 patients treated with intraventricular IFN-alpha-2a over ay long period, we observed the appearance of clinical and EMG signs suggestive of upper and lower motor neuron pathology. These signs improved slightly in one patient after the discontinuation of IFN. It is suggested that this polypeptide may act on specific kinds of nervous cells which selectively suffer together in various well-known neurological diseases.
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页码：153 / 155
页数：3
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