SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-FLUORO-2-THIOCYTOSINE NUCLEOSIDES

被引：13

作者：

BRETNER, M

BALINSKA, M

KRAWIEC, K

KIERDASZUK, B

SHUGAR, D

KULIKOWSKI, T

机构：

[1] POLISH ACAD SCI,INST BIOCHEM & BIOPHYS,PL-02106 WARSAW,POLAND

[2] POLISH ACAD SCI,M NENCKI INST EXPTL BIOL,WARSAW,POLAND

[3] UNIV WARSAW,INST EXPTL PHYS,PL-02089 WARSAW,POLAND

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012445

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two pathways are described for the synthesis of the 2'-deoxynucleosides of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside condensation, (b) by amination of the corresponding nucleosides of 2,4-dithiouracil. Biological activities vs two cell systems are described. The nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the enzyme

引用

页码：657 / 660

页数：4

共 4 条

[1] 2-THIO DERIVATIVES OF DURD AND 5-FLUORO-DURD AND THEIR 5'-MONOPHOSPHATES - SYNTHESIS, INTERACTION WITH TUMOR THYMIDYLATE SYNTHASE, AND IN-VITRO ANTITUMOR-ACTIVITY [J].