MONOFUNCTIONAL ELECTROPHILIC AND NUCLEOPHILIC DERIVATIVES OF MESO-TETRAPHENYLPORPHYRIN FOR ATTACHMENT TO PEPTIDES

被引：24

作者：

MATTHEWS, SE ^{[1
]}

POUTON, CW ^{[1
]}

THREADGILL, MD ^{[1
]}

机构：

[1] UNIV BATH, SCH PHARM & PHARMACOL, BATH BA2 7AY, AVON, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 17期

关键词：

D O I：

10.1039/c39950001809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Nitrophenyl N-[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]carbamate and 5-[4-(N-glycylamino)phenyl]-10,15,20-triphenylporphyrin have been synthesised from a readily prepared monofunctionalised porphyrin; they couple efficiently with the side-chains of extended lysyl and glutamyl peptide derivatives, respectively.

引用

页码：1809 / 1811

页数：3

共 15 条

[1]

Alder A., 1967, J ORG CHEM, V32, P476

[2] MESO-TETRA(HYDROXYPHENYL)PORPHYRINS, A NEW CLASS OF POTENT TUMOR PHOTOSENSITIZERS WITH FAVORABLE SELECTIVITY [J].

BERENBAUM, MC ;

AKANDE, SL ;

BONNETT, R ;

KAUR, H ;

IOANNOU, S ;

WHITE, RD ;

WINFIELD, UJ .

BRITISH JOURNAL OF CANCER, 1986, 54 (05) :717-725

[3] INVIVO BIOLOGICAL-ACTIVITY OF THE COMPONENTS OF HEMATOPORPHYRIN DERIVATIVE [J].

BERENBAUM, MC ;

BONNETT, R ;

SCOURIDES, PA .

BRITISH JOURNAL OF CANCER, 1982, 45 (04) :571-581

[4] IODINATION AND HECK ALKYNYLATION OF 5,15-DIPHENYLPORPHYRIN - A CONVENIENT ENTRY TO ASYMMETRICALLY MESOSUBSTITUTED PORPHYRINS [J].

BOYLE, RW ;

JOHNSON, CK ;

DOLPHIN, D .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (05) :527-528

[5]

Dougherty T J, 1984, Prog Clin Biol Res, V170, P301

[6]

FURMANSKI P, 1988, CANCER RES, V48, P4604

[7] SYNTHESIS OF 2 LINEAR OCTAPEPTIDE FRAGMENTS OF CYCLOSPORIN BY STEPWISE AND FRAGMENT CONDENSATION STRATEGIES [J].

GALPIN, IJ ;

MOHAMMED, AKA ;

PATEL, A ;

PRIESTLEY, G .

TETRAHEDRON, 1988, 44 (06) :1763-1772

[8] THE SYNTHESIS OF POLYAMIDE OLIGONUCLEOTIDE CONJUGATE MOLECULES [J].

HARALAMBIDIS, J ;

DUNCAN, L ;

ANGUS, K ;

TREGEAR, GW .

NUCLEIC ACIDS RESEARCH, 1990, 18 (03) :493-499

[9] RELAXATION ENHANCEMENT OF WATER PROTONS BY MANGANESE(III) PORPHYRINS - INFLUENCE OF PORPHYRIN AGGREGATION [J].

KELLAR, KE ;

FOSTER, N .

INORGANIC CHEMISTRY, 1992, 31 (08) :1353-1359

[10] REGIOSPECIFIC ARYL NITRATION OF MESO-SUBSTITUTED TETRAARYLPORPHYRINS - A SIMPLE ROUTE TO BIFUNCTIONAL PORPHYRINS [J].

KRUPER, WJ ;

CHAMBERLIN, TA ;

KOCHANNY, M .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (11) :2753-2756

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