ENZYMATIC CONVERSION OF BENZO[A]PYRENE LEADING PREDOMINANTLY TO DIOL-EPOXIDE R-7,T-8-DIHYDROXY-T-9,10-OXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE THROUGH A SINGLE ENANTIOMER OF R-7,T-8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE

被引：353

作者：

YANG, SK

MCCOURT, DW

ROLLER, PP

GELBOIN, HV

机构：

[1] NCI,CHEM BRANCH,BETHESDA,MD 20014

[2] NCI,CARCINOGEN METAB & TOXICOL BRANCH,BETHESDA,MD 20014

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1976年 / 73卷 / 08期

关键词：

D O I：

10.1073/pnas.73.8.2594

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

收藏

页码：2594 / 2598

页数：5

相关论文

共 24 条

[1] BELAND FA, 1976, J CHEM SOC CHEM COMM, V3, P84
[2] METABOLIC CONVERSION OF BENZO[ALPHA]PYRENE BY SYRIAN-HAMSTER LIVER-MICROSOMES AND BINDING OF METABOLITES TO DEOXYRIBONUCLEIC ACID
BORGEN, A
DARVEY, H
CASTAGNO.N
CROCKER, TT
RASMUSSE.RE
WANG, IY
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (05) : 502 - 506
[3] CRIEGEE R, 1942, LIEBIGS ANN CHEM, V550, P99
[4] FLETCHER JH, 1974, ADV CHEM SER, P103
[5] GELBOIN HV, 1972, FED PROC, V31, P1298
[6] GELBOIN HV, 1969, CANCER RES, V29, P1272
[7] HAUGEN DA, 1975, J BIOL CHEM, V250, P3567
[8] EFFECTS OF INDUCERS AND EPOXIDE HYDRASE ON METABOLISM OF BENZO[A]PYRENE BY LIVER-MICROSOMES AND A RECONSTITUTED SYSTEM - ANALYSIS BY HIGH PRESSURE LIQUID-CHROMATOGRAPHY
HOLDER, G
YAGI, H
DANSETTE, P
JERINA, DM
LEVIN, W
LU, AYH
CONNEY, AH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (11) : 4356 - 4360
[9] IDENTIFICATION OF MUTAGENIC METABOLITES OF BENZO[A]PYRENE IN MAMMALIAN-CELLS
HUBERMAN, E
SACHS, L
YANG, SK
GELBOIN, HV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (02) : 607 - 611
[10] CARBONIUM-ION AS ULTIMATE CARCINOGEN OF POLYCYCLIC AROMATIC-HYDROCARBONS
HULBERT, PB
[J]. NATURE, 1975, 256 (5513) : 146 - 148