INTESTINAL BACTERIAL ORIGIN OF D-ALANINE IN URINE OF MUTANT MICE LACKING D-AMINO-ACID OXIDASE

被引：54

作者：

KONNO, R

NIWA, A

YASUMURA, Y

机构：

[1] Department of Microbiology, Dokkyo University, School of Medicine

来源：

BIOCHEMICAL JOURNAL | 1990年 / 268卷 / 02期

关键词：

D O I：

10.1042/bj2680263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urine from mutant mice which lack D-amino-acid oxidase contained a large amount of D-alanine. The alanine content was not changed by changes in the dietary composition or by starvation. However, oral administration of an antibiotic, amoxicillin, decreased the urinary alanine to the normal level. These results suggest that the D-alanine is not of dietary origin but of intestinal bacterial origin.

引用

页码：263 / 265

页数：3

共 19 条

[1]

Bright HB., 1975, ENZYMES, V12B, P421

[2] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNAS ENCODING PORCINE KIDNEY D-AMINO-ACID OXIDASE [J].