CIRCADIAN PHASE-DEPENDENT PROTEIN AND TISSULAR BINDING OF 3 LOCAL-ANESTHETICS (BUPIVACAINE, ETIDOCAINE, AND MEPIVACAINE) IN MICE - A POSSIBLE MECHANISM OF THEIR CHRONOTOXICOKINETICS

被引：4

作者：

BRUGUEROLLE, B

PRAT, M

机构：

[1] Medical Pharmacology Laboratory, Faculty of Medicine, F 13385, Marseille, Cedex 5

来源：

CHRONOBIOLOGY INTERNATIONAL | 1992年 / 9卷 / 06期

关键词：

TISSULAR AND PROTEIN BINDING; CHRONOTOXICITY; CHRONOKINETICS; LOCAL ANESTHETICS; BRAIN; CARDIAC AND SERUM LEVELS;

D O I：

10.3109/07420529209064558

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was to investigate the possible influence of the time of administration on bupivacaine (B), etidocaine (E), and mepivacaine (M) protein and tissue (brain and heart) binding. For each anesthetic agent, a single dose of B (20 mg/kg), E (40 mg/kg), or M (60 mg/kg) was administered intraperitoneally at 10:00, 16:00, 22:00, and 04:00 h. Blood and tissue samples were collected 15 min after drug administration. This study documents significant circadian variations in protein and tissue binding of the three local anesthetic agents. We did not demonstrate a temporal relationship between the respective free and tissue levels. Thus, the temporal variations of free plasma, brain, and heart levels do not seem to be involved in the temporal changes of induced mortality.

引用

页码：448 / 452

页数：5

共 14 条

[1]

Bruguerolle B., Jadot G., Valli M., Bouyard L., Bouyard P., Etude chronocinetique de la lidocaine chez le rat, J Pharmacol (Paris), 13, pp. 65-76, (1982)

[2]

Bruguerolle B., Prat M., Temporal changes in bupivacaine kinetics, JPharm Pharmacol, 39, pp. 148-149, (1987)

[3]

Bruguerolle B., Prat M., Orcadian phase-dependent pharmacokinetics and acute toxicity of mepiva-caine, J Pharm Pharmacol, 40, pp. 592-594, (1988)

[4]

Bruguerolle B., Prat M., Temporal variations in the erythrocyte permeability to bupivacaine, etidocaine and mepivacaine in mice, Life Sci, 45, pp. 2587-2589, (1989)

[5]

Bruguerolle B., Prat M., Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice, J Pharm Pharmacol, 42, pp. 201-202, (1990)

[6]

Desch G., Cavadore D., Jullien Y., Mercier L., Descomps B., De Rodez M., Dosage rapide et simultane des principaux anesthesiques locaux de type amide par chromatographie gaz-liquide, Ann Anesth Franc, 2, pp. 158-168, (1981)

[7]

Prat M., Bruguerolle B., Rapid simultaneous gas-liquid chromatographic determination of five local anaesthetic drugs in serum, Clin Chem, 32, (1986)

[8]

Bruguerolle B., Jadot G., Valli M., Et al., A propos de la determination de la fraction libre des medicaments, Therapie, 35, pp. 554-555, (1980)

[9]

Jadot G., Bruguerolle B., Valli M., Bouyard P., Determination rapide de la fraction plasmatique libre des substances medicamenteuses, Ann Biol Clin, 38, pp. 379-380, (1980)

[10]

Tucker G.T., Mather L.E., Pharmacokinetics of local anaesthetic agents, Br J Anaesth, 47, pp. 213-224, (1975)

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