A COLD-ADAPTED MUTANT OF PARAINFLUENZA VIRUS TYPE-3 IS ATTENUATED AND PROTECTIVE IN CHIMPANZEES

被引:25
作者
HALL, SL
SARRIS, CM
TIERNEY, EL
LONDON, WT
MURPHY, BR
机构
[1] Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute ofAllergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MY
关键词
D O I
10.1093/infdis/167.4.958
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A live attenuated cold-adapted parainfluenza virus type 3 (PIV-3) vaccine is being developed to prevent the serious lower respiratory tract disease caused by this virus in infants and young children. This cold-passaged mutant (cp45) was evaluated in seronegative chimpanzees and found to be highly attenuated in both the upper and lower respiratory tracts compared to its wild-type parent. Animals immunized with cp45 were also highly resistant to wild-type PIV-3 challenge. Stability of the attenuation phenotype was demonstrated by the administration to 2 additional chimpanzees of an isolate of cp45 obtained after 10 days of replication in a chimpanzee. It was attenuated in both the upper and lower respiratory tracts. The cp45 virus present in the respiratory tract secretions of chimpanzees retained the temperature-sensitive (ts) phenotype, but some loss of ts property was observed in the isolates. These results provide a basis on which to proceed to clinical trials in seronegative human infants and children.
引用
收藏
页码:958 / 962
页数:5
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