POSTERIOR HYPOTHALAMIC DEAFFERENTATION OR 5,7-DIHYDROXYTRYPTAMINE INHIBIT CORTICOTROPIN-RELEASING HORMONE, ACTH AND CORTICOSTERONE RESPONSES FOLLOWING PHOTIC-STIMULATION

被引：11

作者：

FELDMAN, S ^{[1
]}

WEIDENFELD, J ^{[1
]}

机构：

[1] BIKUR CHOLIM HOSP, ENDOCRINOL LAB, JERUSALEM, ISRAEL

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 02期

关键词：

SEROTONIN; CRH; ACTH; CORTICOSTERONE; POSTERIOR HYPOTHALAMIC DEAFFERENTATION;

D O I：

10.1016/0304-3940(95)11957-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of posterior hypothalamic deafferentation (PHD) or hypothalamic serotonin (5-HT) depletion by 5,7-dihydroxy-tryptamine on corticotropin-releasing hormone (CRH), ACTH and corticosterone (CS) responses, following photic stimulation, was investigated in male rats. In intact animals, photic stimulation caused median eminence (ME) CRH depletion and a rise in serum ACTH and CS, levels. In rats with PHD, in which previous studies have demonstrated 5-HT depletion, or with neurotoxin induced hypothalamic 5-HT reduction, these responses were markedly inhibited. This indicates that the blockage in the release of ME CRH into the portal circulation in rats with hypothalamic 5-HT depletion is responsible for the inhibition of the pituitary-adrenocortical responses following photic stimulation.

引用

页码：143 / 145

页数：3

共 16 条

[1] HYPOTHALAMIC CONTROL OF ADRENOCORTICOTROPIN SECRETION - ADVANCES SINCE THE DISCOVERY OF 41-RESIDUE CORTICOTROPIN-RELEASING FACTOR [J].