DEVELOPMENT OF 2ND-GENERATION MONOCLONAL-ANTIBODIES RECOGNIZING LEWIS(Y/B) ANTIGEN BY ANTIIDIOTYPIC IMMUNIZATION

被引：4

作者：

DURRANT, LG ^{[1
]}

SINGHAL, A ^{[1
]}

JACOBS, E ^{[1
]}

PRICE, MR ^{[1
]}

机构：

[1] UNIV SEATTLE,INST BIOMEMBRANE,SEATTLE,WA

来源：

HYBRIDOMA | 1993年 / 12卷 / 06期

关键词：

D O I：

10.1089/hyb.1993.12.647

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new monoclonal antibodies (Mabs) recognising the Lewis(y/b) hapten of the IgG isotype have been produced following immunisation with rat anti-idiotypic antiserum to C14, an IgM Lewis(y/b) hapten Mab and boosting with C14gp200 antigen. They have the same fine specificity as the original Mab binding to a cell surface and secreted antigen preferentially expressed by colorectal tumour cells.

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页码：647 / 660

页数：14

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