Carboplatin and etoposide in an out-patient schedule for the palliation of advanced non-small-cell lung cancer

被引:3
作者
Aitini, E
Cavazzini, G
Cantore, M
Rabbi, C
Malaspina, R
Truzzi, R
Fazion, S
Pari, F
Mambrini, A
Zamagni, D
Amadori, M
Bertuzzi, A
Natale, F
Smerieri, F
机构
[1] OSPED CARLO POMA,DEPT MED ONCOL,POMA,ITALY
[2] OSPED CARLO POMA,PAIN MANAGEMENT CTR,POMA,ITALY
[3] OSPED CARLO POMA,DEPT INTERNAL MED,POMA,ITALY
[4] USSL 21,DEPT PNEUMOL,MANTOVA,ITALY
关键词
carboplatin; etoposide; advanced non-small-cell lung cancer;
D O I
10.1177/030089169508100608
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims and Background In Western countries, non-small-cell lung cancer is the most important cause of cancer-related death. To date, medical treatment for advanced stages remains of a palliative nature. Methods: Forty-four patients with advanced non-small-cell lung cancer were treated in a phase II study with carboplatin and etoposide (each at 60 mg/m(2) daily) in a 5-day schedule. Among 44 patients, 18 (40%) had stage IIIB disease and 26 (60%) had stage IV disease. Results: Treatment was well tolerated, and the only significant side effect was alopecia. The overall response rate was 27% with 2 complete remissions; median survival time was 10.4 months. One of the 2 patients achieving a complete remission was still alive and disease free at 36 months from the start of therapy. An improvement of performance status was observed in 22 patients (50%). Conclusions The combination of carboplatin and etoposide using this schedule appears to be well tolerated and has some activity in the palliation of advanced non-small-cell lung cancer.
引用
收藏
页码:429 / 431
页数:3
相关论文
共 21 条
[1]  
ALI MF, 1994, P AM SOC CLIN ONCOL, V13, P1225
[2]  
BELANI CP, 1989, J CLIN ONCOL, V7, P1986
[3]  
BONOMI P, 1991, SEMIN ONCOL, V18, P2
[4]   CANCER STATISTICS, 1993 [J].
BORING, CC ;
SQUIRES, TS ;
TONG, T .
CA-A CANCER JOURNAL FOR CLINICIANS, 1993, 43 (01) :7-26
[5]  
BUNN PA, 1989, SEMIN ONCOL, V16, P27
[6]  
CELLERINO R, 1990, LUNG CANCER, V6, P99
[7]  
CLARK PI, 1989, P AM SOC CLIN ONCOL, V8, pA257
[8]  
FEIGAL EG, 1993, SEMIN ONCOL, V20, P185
[9]  
GANZ PA, 1989, CANCER, V63, P1271, DOI 10.1002/1097-0142(19890401)63:7<1271::AID-CNCR2820630707>3.0.CO
[10]  
2-6