REGULATION OF FGF-4 ENHANCER ACTIVITY BY TRANSCRIPTION FACTOR NF-Y

被引：13

作者：

BRYANS, M

LUCAS, JM

KNOBLOCH, TJ

WILKIE, NM

LANG, JC

机构：

[1] OHIO STATE UNIV, DEPT HEMATOL & ONCOL, COLUMBUS, OH 43210 USA

[2] OHIO STATE UNIV, DEPT OTOLARYNGOL, COLUMBUS, OH 43210 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1844

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has minimal effect on activity of the FGF-4 promoter alone. (C) 1995 Academic Press, Inc.

引用

收藏

页码：519 / 527

页数：9

相关论文

共 19 条

[1] ISOLATION OF A REARRANGED HUMAN TRANSFORMING GENE FOLLOWING TRANSFECTION OF KAPOSI-SARCOMA DNA [J].

BOVI, PD ;

BASILICO, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) :5660-5664

[2] EXPRESSION OF THE K-FGF PROTOONCOGENE IS CONTROLLED BY 3' REGULATORY ELEMENTS WHICH ARE SPECIFIC FOR EMBRYONAL CARCINOMA-CELLS [J].

CURATOLA, AM ;

BASILICO, C .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (06) :2475-2484

[3] INTERACTION BETWEEN A NOVEL F9-SPECIFIC FACTOR AND OCTAMER-BINDING PROTEINS IS REQUIRED FOR CELL-TYPE-RESTRICTED ACTIVITY OF THE FIBROBLAST GROWTH-FACTOR-4 ENHANCER [J].

DAILEY, L ;

YUAN, HB ;

BASILICO, C .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :7758-7769

[4] TRANSCRIPTION FACTOR BINDING AND SPACING CONSTRAINTS IN THE HUMAN BETA-ACTIN PROXIMAL PROMOTER [J].

DANILITION, SL ;

FREDERICKSON, RM ;

TAYLOR, CY ;

MIYAMOTO, NG .

NUCLEIC ACIDS RESEARCH, 1991, 19 (24) :6913-6922

[5] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI [J].

DIGNAM, JD ;

LEBOVITZ, RM ;

ROEDER, RG .

NUCLEIC ACIDS RESEARCH, 1983, 11 (05) :1475-1489

[6] A MULTIPLICITY OF CCAAT BOX-BINDING PROTEINS [J].

DORN, A ;

BOLLEKENS, J ;

STAUB, A ;

BENOIST, C ;

MATHIS, D .

CELL, 1987, 50 (06) :863-872

[7] HOMOLOGOUS RECOGNITION OF A PROMOTER DOMAIN COMMON TO THE MSV LTR AND THE HSV TK GENE [J].

GRAVES, BJ ;

JOHNSON, PF ;

MCKNIGHT, SL .

CELL, 1986, 44 (04) :565-576

[8]

HASAN S, 1994, J BIOL CHEM, V269, P25042

[9]

LUCAS JM, 1994, ONCOL RES, V6, P139

[10] TRANSCRIPTIONAL REGULATION OF THE MURINE K-FGF GENE IN EMBRYONIC-CELL LINES [J].

MA, YG ;

ROSFJORD, E ;

HUEBERT, C ;

WILDER, P ;

TIESMAN, J ;

KELLY, D ;

RIZZINO, A .

DEVELOPMENTAL BIOLOGY, 1992, 154 (01) :45-54