Twenty cases of molluscum have been evaluated for the clinical effectiveness of 70% PVP‐iodine solution and 50% salicylic acid plaster therapy. The treatment works well, and the shorter duration of treatment necessary for healing is statistically significant as compared with the duration of treatment for controls who lacked either one of the applications. Although the working mechanism for the effectiveness is not known, the treatment is characterized as a less expensive and less painful procedure. All patients were completely healed after a mean treatment of 26 days; there were no adverse effects. This therapy is recommended for the office patient, young children, diabetic patients, and those with multiple lesions. Copyright © 1990, Wiley Blackwell. All rights reserved