HLA ANTIGENS IN ITALIAN MULTIPLE-SCLEROSIS PATIENTS

被引：10

作者：

LAMANTIA, L

ILLENI, MT

MILANESE, C

SALMAGGI, A

EOLI, M

PELLEGRIS, G

NESPOLO, A

机构：

[1] IST NAZL NEUROL C BESTA,ANAL LAB,MILAN,ITALY

[2] IST NAZL TUMORI,SERV IMMUNOEMATOL,I-20133 MILAN,ITALY

[3] IST NAZL NEUROL C BESTA,DIV NEUROL,I-20133 MILAN,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 12卷 / 01期

关键词：

MULTIPLE SCLEROSIS; HLA; CEREBROSPINAL FLUID;

D O I：

10.1007/BF02337618

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 show a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

引用

页码：81 / 86

页数：6

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