EFFECT OF EGG-YOLK LECITHINS AND COMMERCIAL SOYBEAN LECITHINS ON INVITRO SKIN PERMEATION OF DRUGS

被引：41

作者：

MAHJOUR, M

MAUSER, B

RASHIDBAIGI, Z

FAWZI, MB

机构：

[1] Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Morris Plains, NJ 07950

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 14卷 / 03期

关键词：

TRANSDERMAL DRUG DELIVERY; SKIN PERMEATION ENHANCERS; LECITHINS; SKIN PERMEATION OF PROCATEROL; OXYMORPHONE; DEXTROMETHORPHAN AND DIPHENHYDRAMINE;

D O I：

10.1016/0168-3659(90)90164-O

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The skin permeation enhancement effects of two commercial soy lecithins and two types of egg yolk lecithin were investigated in vitro. Hairless mouse skin was used as a model membrane, with several compounds having different octanol-water partition coefficients as model drugs. The commercial soy lecithins in tetraglycol significantly (p < 0.05) increased the transport of procaterol, dextromethorphan, oxymorphone and diphenhydramine across the skin. Both egg yolk lecithins, in propylene glycol, improved the permeability of oxymorphone similarly and to a greater degree than the commercial soy lecithins (p < 0.05). The effect of egg yolk lecithins on procaterol transport was less than that of the commercial soy lecithins. The lecithins improved the skin permeability of procaterol, which has the lowest octanol-water partition coefficient, more than those compounds with higher octanol-water partition coefficients.

引用

页码：243 / 252

页数：10

共 16 条

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