IMPROVING EFFECTS OF FG-7080, A SEROTONIN REUPTAKE INHIBITOR, ON SCOPOLAMINE-INDUCED PERFORMANCE DEFICITS OF MEMORY TASKS IN RATS

被引：9

作者：

MIURA, N ^{[1
]}

NAKATA, N ^{[1
]}

TANAKA, Y ^{[1
]}

HIRAGA, Y ^{[1
]}

IKEDA, Y ^{[1
]}

OHATA, H ^{[1
]}

IWASAKI, T ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST PSYCHOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 62卷 / 02期

关键词：

SEROTONIN REUPTAKE INHIBITOR; LEARNING AND MEMORY; SCOPOLAMINE;

D O I：

10.1254/jjp.62.203

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel serotonin reuptake inhibitor, (-)trans 4-(4-fluorophenyl)-3-(4-methoxyphenoxymethyl)piperidine hydrochloride (FG-7080), was investigated for its effects on scopolamine-induced impairments in memory tasks of rats. In the radial-arm maze task, FG-7080 (3 mg/kg, p.o.) improved the impaired performance. FG-7080 (I mg/kg, p.o.) administered before the acquisition trial reduced the acquisition deficits in the passive avoidance task. Thus, the compound showed improving effects in the appetitive and aversive memory tasks. These findings suggest that FG-7080 may ameliorate the cognitive impairments caused by the cholinergic dysfunction.

引用

页码：203 / 206

页数：4

共 15 条

[1] EVIDENCE FOR A POSSIBLE FUNCTIONAL INTERACTION BETWEEN SEROTONERGIC AND CHOLINERGIC MECHANISMS IN MEMORY RETRIEVAL [J].